Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation
نویسندگان
چکیده
An efficient and practical protocol has been developed to synthesize 5,6-dihydroindolo[1,2-a]quinoxaline derivatives by CuI-catalyzed intramolecular N-arylation under microwave irradiation. This method rapidly afforded the tetracyclic products with good to excellent yields (83-97%) in short reaction times (45-60 min).
منابع مشابه
A concise and efficient synthesis of benzimidazo[1,2-c]quinazolines through CuI-catalyzed intramolecular N-arylations
A series of functionalized benzimidazo[1,2-c]quinazoline derivatives was obtained in excellent yields under mild conditions through a CuI-catalyzed Ullmann N-arylation starting from easily available starting materials.
متن کاملCopper-catalyzed CuAAC/intramolecular C–H arylation sequence: Synthesis of annulated 1,2,3-triazoles
Step-economical syntheses of annulated 1,2,3-triazoles were accomplished through copper-catalyzed intramolecular direct arylations in sustainable one-pot reactions. Thus, catalyzed cascade reactions involving [3 + 2]-azide-alkyne cycloadditions (CuAAC) and C-H bond functionalizations provided direct access to fully substituted 1,2,3-triazoles with excellent chemo- and regioselectivities. Likewi...
متن کاملDicationic Ionic Liquid as the Recyclable Catalyst for the Synthesis of Quinoxaline Derivatives
An efficient and eco-friendly protocol for the synthesis of quinoxaline derivatives employing a condensation reaction between 1,2-diketone and 1,2-diaminobenzene derivative has been developed. The reaction of 1,2-diketone and 1,2-diaminobenzene derivative was carried out in water at room temperature using 10 mol% of task-specific dicationic ionic liquid as a catalyst. The results show that...
متن کاملEfficient and eco-friendly synthesis of quinoxalines derivatives catalyzed by acidic ionic liquids at room temperature
In this research, we have developed cheap recyclable and task-specific acidic ionic liquids (AILs) 1-hydrogen-3-methylimidazolium hydrogen sulfate [Hmim]HSO4, 1-hydrogen-3-methylimidazolium chloride [Hmim]Cl, 2-pyrrolidonium hydrogensulfate [Hnhp]HSO4 and applied them in acid catalyzed synthesis of quinoxaline derivatives from 1,2-phenylendiamines and 1,2-dicarbonyl compounds. The products coul...
متن کاملEfficient and eco-friendly synthesis of quinoxalines derivatives catalyzed by acidic ionic liquids at room temperature
In this research, we have developed cheap recyclable and task-specific acidic ionic liquids (AILs) 1-hydrogen-3-methylimidazolium hydrogen sulfate [Hmim]HSO4, 1-hydrogen-3-methylimidazolium chloride [Hmim]Cl, 2-pyrrolidonium hydrogensulfate [Hnhp]HSO4 and applied them in acid catalyzed synthesis of quinoxaline derivatives from 1,2-phenylendiamines and 1,2-dicarbonyl compounds. The products coul...
متن کامل